In an interdisciplinary collaboration, OSUMC scientists and physicians align their efforts to identify the etiology, prevention, and treatment of pancreatic cancer.
Pancreatic Cancer References
Bloomston M, Ellison EC, Muscarella P, Al-Saif O, Martin EW, Melvin WS, Frankel WL. Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer. Ann Surg Oncol 2007 Jan;14(1):211-217.
Zervos EE, Tanner SM, Osborne DA, Bloomston M, Rosemurgy AS, Ellison EC, Melvin WS, de la Chapelle A. Differential gene expression in patients genetically predisposed to pancreatic cancer. J Surg Res 2006 Oct;135(2):317-322.
Bloomston M, Bekaii-Saab TS, Kosuri K, Cowgill SW, Melvin Ws, Ellison EC, Muscarella P 2nd. Preoperative carbohydrate antigen 19-9 is most predictive of malignancy in older jaundiced patients undergoing pancreatic resection. Pancreas 2006 Oct;33(3):246-249.
Li J, Zhu J, Melvin WS, Bekaii-Saab TS, Chen CS, Muscarella P. A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth. J Gastrointest Surg 2006 Feb;10(2):207-214.
Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD. Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). Biochemistry 2005 Oct 11;44(40):13246-13256.
Li J, Melvin WS, Tsai MD, Muscarella P. The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner. Biochemistry 2004 Apr 13;43(14):4394-9.
Li J, Weghorst CM, Tsutsumi M, Poi MJ, Knobloch TJ, Castro BC, Melvin WS, Tsai MD, Muscarella P. Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors. Carcinogenesis. 2004 Feb;25(2):263-268.
Melvin WS. Minimally invasive pancreatic surgery. Am J Surg 2003 Sep;186(3):274-278.
Li J, Qin D, Knobloch TJ, Tsai MD, Weghorst CM, Melvin WS, Muscarella P. Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A. Biochem Biophys Res Commun. 2003 May 2;304(2):241-247.
Muscarella P, Knobloch TJ, Ulrich AB, Castro BC, Moniaux N, Wittel UA, Melvin WS, Pour PM, Song H, Gold B, Batra SK, Weghorst CM. Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells. Gene 2001 Oct 31;278(1-2):235-243.
Ikramuddin S, Lucus J, Ellison EC, Schirmer WJ, Melvin WS. Detection of aerosolized cells during carbon dioxide laparoscopy. J Gastrointest Surg 1998 Nov-Dec;2(6):58—583, discussion 584.
Boros LG, Brandes JL, Lee WN, Cascante M, Puigjaner J, Revesz E, Bray TM, Schirmer WJ, Melvin WS. Thiamine supplementation to cancer patients: a double edged sword. Anticancer Res 1998 Jan-Feb;18(1B):595-602.
Muscarella P, Melvin WS, Fisher WE, Foor J, Ellison EC, Herman JG, Schirmer WJ, Hitchcock CL, DeYoung BR, Weghorst CM. Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation. Cancer Res 1998 Jan 15;58(2):237-240.
Muscarella P, Boros LG, Fisher WE, Rink C, Melvin WS. Oral dehydroepiandrosterone inhibits the growth of human pancreatic cancer in nude mice. J Surg Res. 1998 Oct;79(2):154-157.
Melvin WS, Buekers KS, Muscarella P, Johnson JA, Schirmer WJ, Ellison EC. Outcome analysis of long-term survivors following pancreaticoduodenectomy. J Gastrointest Surg 1998 Jan-Feb;2(1):72-78.
Boros LG, Lee PW, Brandes JL, Cascante M, Muscarella P, Schirmer WJ, Melvin WS, Ellison EC. Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism. Med Hypotheses. 1998 Jan;50(1):55-59.
Boros LG, Puigjaner J, Cascante M, Lee WN, Brandes JL, Bassilian S, Yusuf FI, Williams RD, Muscarella P, Melvin WS, Schirmer WJ. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res 1997 Oct 1;57(19):4242-4248.
Melvin WS, Boros LG, Muscarella P, Brandes JL, Johnson JA, Fisher WE, Schirmer WJ, Ellison EC. Dehydroepiandrosterone-sulfate inhibits pancreatic carcinoma cell proliferation in vitro and in vivo. Surgery 1997 Apr;121(4):392-397.
Schirmer WJ, Melvin WS, Rush RM, O’Dorisio TM, Pozderac RV, Olsen JO, Ellison EC. Indium-111-pentetreotide scanning versus conventional imaging techniques for the localization of gastrinoma. Surgery 1995 Dec;118(6):1105-113, discussion 1113-1114.
